Ethanol → 5-Cyano-2-hydroxybenzoic acid
反応式
C(O)C.C([O:11][C:12](=[O:29])[C:13]1[CH:18]=[C:17]([C:19]#[N:20])[CH:16]=[CH:15][C:14]=1[O:21]CC1C=CC=CC=1)C1C=CC=CC=1>[Pd].O1CCCC1>[C:19]([C:17]1[CH:18]=[C:13]([C:12]([OH:29])=[O:11])[C:14]([OH:21])=[CH:15][CH:16]=1)#[N:20]参加物
5
実験手順
Ethanol (10 mL) and tetrahydrofuran (10 mL) were added to 2-benzyloxy-5-cyanobenzoic acid benzyl ester (446 mg, 1.3 mmol) and 5% palladium on carbon (45 mg), and the mixture was hydrogenated at room temperature for 2 hours. After the insoluble matter was filtered off, the solvent was evaporated under reduced pressure to give the title compound (212 mg, 100.0%) as a white solid.
後処理
- filtrationAfter the insoluble matter was filtered off
- customthe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-eab15355bce64c8bbc10a08fb4923ec7
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07700655B2
反応ノート
読み込み中…