Tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate → 8-Boc-3,8-diaza-bicyclo(3.2.1)octane

HRID 645351

反応式

HRID 645351 の反応式
[C:1]([O:5][C:6]([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][N:11](CC1C=CC=CC=1)[CH2:12]2)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[C:1]([O:5][C:6]([N:8]1[CH:9]2[CH2:15][CH2:14][CH:13]1[CH2:12][NH:11][CH2:10]2)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 1

HCID 15740907Tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate

生成物 1

HCID 157409088-Boc-3,8-diaza-bicyclo(3.2.1)octane

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 3-benzyl-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (13.0 g, 43.0 mmol), palladium on carbon (4.0 g, 5%) and ethanol (100 ml, 99%) was stirred under hydrogen. The mixture was filtered on celite, dried and evaporated. A white powder was isolated. Yield 8.4 g (92%). Mp 103.4-106° C.

後処理

  1. filtrationThe mixture was filtered on celite
  2. customdried
  3. customevaporated
  4. customA white powder was isolated

出典と根拠

ORDレコード
ord-22b8c09f52dd4a4584e4577c0b55a3a0
出典データセット
uspto-grants-2010_04
特許番号
US07704991B2

関連ノート

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