Dimethylamine → N,N-dimethyl-6-nitropyridin-3-amine

HRID 645376

反応式

HRID 645376 の反応式
[CH3:1][NH:2][CH3:3].Br[C:5]1[CH:6]=[CH:7][C:8]([N+:11]([O-:13])=[O:12])=[N:9][CH:10]=1>O1CCCC1.C(O)C>[CH3:1][N:2]([CH3:3])[C:5]1[CH:10]=[N:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1

参加物

5

反応物 2

HCID 674DimethylamineHCID 8176205-Bromo-2-nitropyridine

生成物 1

HCID 21897368N,N-dimethyl-6-nitropyridin-3-amine

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
140 °C

実験手順

6 ml of a 2M solution of dimethylamine in tetrahydrofuran are added to a solution of 1 g of 5-bromo-2-nitropyridine in 5 ml of ethanol. The reaction mixture is heated at 140° C. for 2 hours in a microwave device. After cooling, the solid formed is separated off and washed with ethyl ether to give 850 mg of N,N-dimethyl-6-nitropyridine-3-amine in the form of a yellow solid.

後処理

  1. temperatureAfter cooling
  2. customthe solid formed
  3. customis separated off
  4. washwashed with ethyl ether

出典と根拠

ORDレコード
ord-df43c36cf54a4690b826f0ce9289bccb
出典データセット
uspto-grants-2010_04
特許番号
US07704989B2

関連ノート

読み込み中…