Dimethylformamide → HCID 70469256、化合物

HRID 64583

反応式

HRID 64583 の反応式
[OH:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[C:16](C)=[N:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)=[CH:4][CH:3]=1.[H-].[Na+].[H][H].Br[CH:25]([CH3:32])[CH:26]=[CH:27][C:28]([O:30][CH3:31])=[O:29].[CH3:33]N(C)C=O>O>[CH3:33][C:7]1([O:6][C:5]2[CH:4]=[CH:3][C:2]([O:1][CH:25]([CH3:32])[CH:26]=[CH:27][C:28]([O:30][CH3:31])=[O:29])=[CH:19][CH:18]=2)[N:8]=[C:9]2[C:14]([CH:13]=[CH:12][CH:11]=[CH:10]2)=[N:15][CH2:16]1

参加物

7

反応物 5

HCID 6228Dimethylformamide2 回HCID 24758Sodium hydrideHCID 136705382-(4-Hydroxyphenoxy)-3-methylquinoxalineHCID 54128087Methyl 4-bromo-2-pentenoateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 70469256HCID 70469256、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

In a nitrogen atmosphere, add a solution of 5.4 g (0.02 mole) 2-(4-hydroxyphenoxy)-3-methylquinoxaline in 30 cc dimethylformamide to 0.9 g (0.02 mole) 57% sodium hydride in 20 cc dimethylformamide at about 20° C. When the evolution of hydrogen ceases, add 3.9 g (0.02 mole) methyl 4-bromo-2-pentenoate. Heat the reaction mixture at approximately 80° C. until the reaction is complete. Pour the reaction mixture into water and extract with ether. Combine the ethereal extracts and dry over magnesium sulfate. Removal of the ether gives the desired product.

後処理

  1. extractionextract with ether
  2. dry with materialdry over magnesium sulfate
  3. customRemoval of the ether

出典と根拠

ORDレコード
ord-aa9f6b8071fc48d085f88192195dc687
出典データセット
uspto-grants-1986_09
特許番号
US04609396

関連ノート

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