Hydrochloric Acid → 2-(4-Bromophenoxy)-2-methyl-1-(pyrrolidin-1-yl)propan-1-one

HRID 646124ノート

反応式

HRID 646124 の反応式
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:6][C:7]1[CH:19]=[CH:18][C:10]([O:11][C:12]([CH3:17])([CH3:16])[C:13](Cl)=[O:14])=[CH:9][CH:8]=1.Cl>CC#N.[Cl-].[Na+].O>[Br:6][C:7]1[CH:19]=[CH:18][C:10]([O:11][C:12]([CH3:16])([CH3:17])[C:13]([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[O:14])=[CH:9][CH:8]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 31268PyrrolidineHCID 45923264HCID 45923264、化合物

生成物 1

HCID 686947812-(4-Bromophenoxy)-2-methyl-1-(pyrrolidin-1-yl)propan-1-one収率 94.3%

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒2 回HCID 57417360Sodium chloride; water溶媒

実験手順

Pyrrolidine (1.54 g, 21.6 mmol) in anhydrous MeCN (10 mL) was added with stirring to 2-(4-bromophenoxy)-2-methylpropanoyl chloride (2 g, 7.2 mmol) in anhydrous MeCN (10 mL) at 0° C. The mixture was stirred at room temperature for 18 h and acidified with HCl (aq. 1M, 40 mL). Brine was added and the mixture was extracted with CH2Cl2. The combined extracts were washed with NaHCO3 (aq. sat) and brine, dried (Na2SO4), and concentrated to give the sub-title compound (2.12 g, 94%).

後処理

  1. extractionthe mixture was extracted with CH2Cl2
  2. washThe combined extracts were washed with NaHCO3 (aq. sat) and brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-1a2c603c73604cefa9e76b385285ffd3
出典データセット
uspto-grants-2010_04
特許番号
US07705023B2

反応ノート

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