Etolotifen → HCID 88677769、化合物
反応式
[OH:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][C:13](=[C:16]2[C:25]3[CH:24]=[CH:23][S:22][C:21]=3[C:20](=O)[CH2:19][C:18]3[CH:27]=[CH:28][CH:29]=[CH:30][C:17]2=3)[CH2:12][CH2:11]1.Cl.[NH2:32][OH:33]>N1C=CC=CC=1>[OH:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][N:10]1[CH2:11][CH2:12][C:13](=[C:16]2[C:25]3[CH:24]=[CH:23][S:22][C:21]=3[C:20](=[N:32][OH:33])[CH2:19][C:18]3[CH:27]=[CH:28][CH:29]=[CH:30][C:17]2=3)[CH2:14][CH2:15]1参加物
4
実験手順
6.0 g 4-{1-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]piperidin-4-ylidene}-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)one and 0.95 g hydroxylaminehydrochlorid in 70 ml pyridine are refluxed for 12 hours. After elimination of the pyridine by distillation, ethanol and a little water are added to the residue and the title compound is crystallised out as the hydrochlorid (Mt. p. 240°-243°).
後処理
- distillationAfter elimination of the pyridine by distillation, ethanol