Thionyl Chloride → HCID 20485604、化合物
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])O)[CH:2]=1.S(Cl)([Cl:19])=O>C(Cl)(Cl)Cl>[ClH:15].[Cl:19][CH:7]([C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[Cl:16]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a 100 ml Erlenmeyer flask equipped with a reflux condensor is added 2.54 gm of 3-pyridyl-2,4-dichlorophenylcarbinol and 30 ml of chloroform. The system is cooled to 0° C. and 1.31 gm (1.2 equivalents) of thionyl chloride in 25 ml of chloroform is added over 1/2-hour. After addition of the thionyl chloride, the system is allowed to come to room temperature and stirred there for 2 hours. The system is then heated at reflux for 1 hour. The chloroform is removed by stripping to give the alpha-chloro-alpha-(3-pyridyl)-2,4-dichlorotoluene hydrochloride salt.