Water → 3-Chloro-5-fluoro-2-hydroxybenzaldehyde

HRID 647201ノート

反応式

HRID 647201 の反応式
[OH-:1].[Na+].[OH2:3].[Cl:4][C:5]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:6]=1O.[CH:13](Cl)(Cl)Cl>>[Cl:4][C:5]1[C:6]([OH:3])=[C:7]([CH:8]=[C:9]([F:11])[CH:10]=1)[CH:13]=[O:1]

参加物

5

反応物 4

HCID 962WaterHCID 6212Chloroform2 回HCID 14798Sodium HydroxideHCID 748142-Chloro-4-fluorophenol

生成物 1

HCID 27827493-Chloro-5-fluoro-2-hydroxybenzaldehyde

実験手順

Sodium hydroxide (50 g.) was dissolved in 70 ml. of water. 2-Chloro-4-fluorophenol (10 g., 0.068 mole) was added and then chloroform (30 ml.) The mixture was refluxed for two hours. Addition of chloroform (30 ml.) and reflux for 2 hours was twice repeated. The reaction mixture was cooled to room temperature and crude product recovered as the sodium salt by filtration. The crude was taken into water and acidified with 1 N hydrochloric acid to yield product (6.6 g.) in the free phenolic form. The latter was chromatographed on 200 g. of silica gel, with 1:1 methylene chloride:hexane as eluant. The column was monitored by tlc. Clean product containing fractions were combined and evaporated to dryness to yield purified 3-chloro-5-fluoro-2-hydroxybenzaldehyde [3.08 g.; m.p. 81°-83° C., Rf 0.49 (1:1 methylene chloride:hexane); ir (CH2Cl2) 1658, 1460, 1439, 1289, 1230, 1116 cm-1 ].

後処理

  1. temperaturereflux for 2 hours
  2. filtrationcrude product recovered as the sodium salt by filtration
  3. customto yield product (6.6 g.) in the free phenolic form
  4. customThe latter was chromatographed on 200 g
  5. additioncontaining fractions
  6. customevaporated to dryness
  7. customto yield
  8. custompurified 3-chloro-5-fluoro-2-hydroxybenzaldehyde [3.08 g.; m.p. 81°-83° C., Rf 0.49 (1:1 methylene chloride:hexane); ir (CH2Cl2) 1658, 1460, 1439, 1289, 1230, 1116 cm-1 ]

出典と根拠

ORDレコード
ord-67150b2834924e5da01af65752dc67cb
出典データセット
uspto-grants-1983_10
特許番号
US04407811

反応ノート

読み込み中…