2-Methyl-6-nitro-1,3-benzoxazol-4-ol → 6-Amino-2-methylbenzo[d]oxazol-4-ol
反応式
[N+:1]([C:4]1[CH:13]=[C:12]([OH:14])[C:7]2[N:8]=[C:9]([CH3:11])[O:10][C:6]=2[CH:5]=1)([O-])=O.[H][H]>C1COCC1.CO.[Pd]>[NH2:1][C:4]1[CH:13]=[C:12]([OH:14])[C:7]2[N:8]=[C:9]([CH3:11])[O:10][C:6]=2[CH:5]=1参加物
6
実験手順
To a solution of 6-nitro-4-hydroxy-2-methylbenzoxazole (5.1 g, 0.026 mole) in THF (100 ml) and methanol (50 ml) were added about 0.5 g of 10 percent palladium on carbon. The mixture was placed on the Parr-shaker apparatus and hydrogenated two hours. At this time hydrogen uptake was complete (6.3 psi, 0.079 mole). The catalyst was removed and the solvents were removed under reduced pressure. The resulting off-white solid (4.1 g, 97.0 percent) was collected and dried. TLC showed the product to be pure. A ninhydrin test for amines was positive. A silver test for hydroxylamine was negative.
後処理
- customwas placed on the Parr-shaker apparatus and hydrogenated two hours
- customThe catalyst was removed
- customthe solvents were removed under reduced pressure
- customThe resulting off-white solid (4.1 g, 97.0 percent) was collected
- customdried
出典と根拠
- ORDレコード
- ord-e664e72264094f2dbd26e2c171168d8e
- 出典データセット
- uspto-grants-1983_10
- 特許番号
- US04407930
反応ノート
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