Water → 3-(N-n-Heptadecylcarbamoyl)oxypropan-1-ol

HRID 647272ノート

反応式

HRID 647272 の反応式
[CH2:1]([N:18]=[C:19]=[O:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].O.C(Cl)(Cl)Cl.[CH2:26]([OH:30])[CH2:27][CH2:28][OH:29]>C(Cl)Cl>[CH2:1]([NH:18][C:19]([O:29][CH2:28][CH2:27][CH2:26][OH:30])=[O:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

参加物

6

反応物 4

HCID 962WaterHCID 6212ChloroformHCID 104421,3-PropanediolHCID 135601031-Isocyanatoheptadecane

生成物 1

HCID 135601043-(N-n-Heptadecylcarbamoyl)oxypropan-1-ol収率 47.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In a mixture of 5.7 g of 1,3-propanediol and 30 ml of methylene chloride is dissolved 5.0 g of n-heptadecyl isocyanate and the mixture is stirred at room temperature overnight. To the reaction mixture are added 20 ml each of water and chloroform, and the organic layer is taken and concentrated to dryness. Then, silica gel column chromatography is carried out [eluent:chloroform-water (97:3)] and the eluate is concentrated to dryness. The procedure provides 3.0 g of the above-indicated compound as colorless crystals.

後処理

  1. concentrationconcentrated to dryness
  2. concentrationthe eluate is concentrated to dryness

出典と根拠

ORDレコード
ord-0eb66856d89f445ca8a74959e6e21846
出典データセット
uspto-grants-1983_10
特許番号
US04408052

反応ノート

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