Hydrogen Bromide → HCID 13386245、化合物

HRID 647446ノート

反応式

HRID 647446 の反応式
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([O:12][C:13]3[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=3)[N:8]=[CH:9]2)=[CH:4][CH:3]=1.Br.O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(=O)C>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([O:12][C:13]3[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=3)[N:8]=[CH:9]2)=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 260Hydrogen BromideHCID 962WaterHCID 10340Sodium CarbonateHCID 133862447-Chloro-3-(4-methoxyphenoxy)isoquinoline

生成物 1

HCID 13386245HCID 13386245、化合物収率 90.7%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

7-Chloro-3-(4-methoxyphenoxy)isoquinoline (3.50 g) was refluxed in a mixture of acetic acid (25 ml) and a solution of hydrogen bromide (25 ml, 48%) for 3 hrs. The mixture was cooled, poured into water, neutralized with sodium carbonate and extracted with ethyl acetate. The extract was washed thoroughly with water, dried (MgSO4) and evaporated to give 4-[(7-chloroisoquinolin-3-yl)oxy]phenol (3.02 g) as brown solid, mp 190° C.

後処理

  1. temperatureThe mixture was cooled
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed thoroughly with water
  4. dry with materialdried (MgSO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-a7badf5ce5ce4463ab5496a2ce67a1b9
出典データセット
uspto-grants-1983_10
特許番号
US04409017

反応ノート

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