Methomyl → Methyl N-[[[[[(5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)(methyl)amino]sulfinyl]methylamino]carbonyl]oxy]ethanimidothioate

HRID 647793

反応式

HRID 647793 の反応式
[CH3:1][NH:2][C:3]([O:5][N:6]=[C:7]([S:9][CH3:10])[CH3:8])=[O:4].[S:11](Cl)(Cl)=[O:12].[CH3:15][C:16]1([CH3:25])[CH2:21][O:20][P:19]([NH:23][CH3:24])(=[S:22])[O:18][CH2:17]1>N1C=CC=CC=1>[CH3:15][C:16]1([CH3:25])[CH2:17][O:18][P:19]([N:23]([CH3:24])[S:11]([CH2:1][NH:2][C:3]([O:5][N:6]=[C:7]([S:9][CH3:10])[CH3:8])=[O:4])=[O:12])(=[S:22])[O:20][CH2:21]1

参加物

5

反応物 3

HCID 4109MethomylHCID 24386Thionyl ChlorideHCID 2549645,5-Dimethyl-2-(methylamino)-1,3,2lambda~5~-dioxaphosphinane-2-thione

生成物 1

HCID 86739078Methyl N-[[[[[(5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)(methyl)amino]sulfinyl]methylamino]carbonyl]oxy]ethanimidothioate

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Methyl N-[[[[[(5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)(methyl)amino]sulfinyl]methylamino]carbonyl]oxy]ethanimidothioate was prepared by the procedure employed in Example 9, by reacting methyl N-[[(methylamino)carbonyl]oxy]ethanimidothioate (2.43 g, 0.015 mole), thionyl chloride (1.79 g, 0.015 mole), and 5,5-dimethyl-2-methylamino-2-thioxo-1,3,2-dioxaphosphorinan (2.93 g, 0.015 mole) in pyridine (10 ml). Recrystallization from chloroform-hexane afforded 3.0 g of needles of the formula below, mp 112~114°. ##STR33##

後処理

  1. customRecrystallization from chloroform-hexane

出典と根拠

ORDレコード
ord-9565aca774ea492c939ef665622c8f8d
出典データセット
uspto-grants-1983_10
特許番号
US04410518

関連ノート

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