Dl-Phenylalanine → D-phenylalanine N-carbobenzoxy-D-aspartic acid

HRID 64785

反応式

HRID 64785 の反応式
[NH2:1][CH:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.S(=O)(=O)(O)O.[C:18]([NH:28][C@@H:29]([C:34]([OH:36])=[O:35])[CH2:30][C:31]([OH:33])=[O:32])([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19]>O>[C:18]([NH:28][C@@H:29]([C:34]([OH:36])=[O:35])[CH2:30][C:31]([OH:33])=[O:32])([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19].[NH2:1][C@@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 994Dl-PhenylalanineHCID 1118Sulfuric AcidHCID 5289152(2R)-2-(((benzyloxy)carbonyl)amino)butanedioic acid

生成物 1

HCID 13714281D-phenylalanine N-carbobenzoxy-D-aspartic acid収率 32.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Eight grams of DL-phenylalanine and 1.2 g of sulfuric acid was suspended in 100 ml of water at 40° C. Ten grams of N-carbobenzoxy-D-aspartic acid was added to the solution over five hours, while this solution was continuously stirred. The resulting crystal was separated, washed with 10 ml of water and dried to give 5.2 g of a D-phenylalanine N-carbobenzoxy-D-aspartic acid. Analysis revealed that the optical purity of the D-phenylalnine was 98%.

後処理

  1. customThe resulting crystal was separated
  2. washwashed with 10 ml of water
  3. customdried

出典と根拠

ORDレコード
ord-987bea95ecff469face1ae081f9f5f8e
出典データセット
uspto-grants-1986_09
特許番号
US04610827

関連ノート

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