Water → 4-Chloro-2-fluorobenzoic acid

HRID 648286

反応式

HRID 648286 の反応式
[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH3:9].[O-:10][Mn](=O)(=O)=O.[K+].[OH2:16]>>[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:10])=[O:16]

参加物

4

反応物 3

HCID 962WaterHCID 516875Potassium PermanganateHCID 5206304-Chloro-2-fluorotoluene

生成物 1

HCID 991524-Chloro-2-fluorobenzoic acid

実験手順

A mixture of 2-fluoro-4-chlorotoluene (25.05 g), KMnO4 (55.04 g) and water (400 ml) is heated to reflux for about 5 hr. The reaction is then worked up by filtering while hot through Celite and the filtrate is acidified with 2 N HCl. White crystals are filtered off, dissolved in ether and washed with water and brine, dried over sodium sulfate, filtered and evaporated to yield 2-fluoro-4-chlorobenzoic acid.

後処理

  1. temperatureis heated
  2. temperatureto reflux for about 5 hr
  3. filtrationby filtering while hot through Celite
  4. filtrationWhite crystals are filtered off
  5. dissolutiondissolved in ether
  6. washwashed with water and brine
  7. dry with materialdried over sodium sulfate
  8. filtrationfiltered
  9. customevaporated

出典と根拠

ORDレコード
ord-fe95aca8fcee4fd08b57c1ccc7c845a0
出典データセット
uspto-grants-1983_10
特許番号
US04411912

関連ノート

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