Diethyl Ether → 2-[4-(5-Formyl-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro-[2,3-c]pyridine

HRID 649635ノート

反応式

HRID 649635 の反応式
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][C:19]2[C:22]3[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=3[O:24][C:18]=2[CH2:17]1.CCOCC>C1COCC1.O=[Mn]=O>[CH:2]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][C:19]2[C:22]3[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=3[O:24][C:18]=2[CH2:17]1)=[O:1]

参加物

5

反応物 2

HCID 3283Diethyl EtherHCID 212432642-[4-(5-Hydroxymethyl-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine

生成物 1

HCID 212432602-[4-(5-Formyl-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro-[2,3-c]pyridine

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒2 回HCID 8028Tetrahydrofuran溶媒

実験手順

37.4 g of 2-[4-(5-hydroxymethyl-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine are dissolved in 1.6 l of THF, and 300 ml of ether are added. While stirring, 55 g of MnO2 are added. The mixture is stirred at 20° for 16 hours, a further 100 g of MnO2 are added in portions, and the mixture is stirred at 20° for a further 100 hours. After filtration and the usual working up, 2-[4-(5-formyl-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine is obtained.

後処理

  1. stirringThe mixture is stirred at 20° for 16 hours
  2. stirringthe mixture is stirred at 20° for a further 100 hours
  3. filtrationAfter filtration

出典と根拠

ORDレコード
ord-63ec048a3b844ca39193b14630232c87
出典データセット
uspto-grants-1988_04
特許番号
US04740602

反応ノート

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