Dimethylamine, hydrochloride → (s)-(1-Dimethylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester

HRID 651108

反応式

HRID 651108 の反応式
Cl.[CH3:2][NH:3][CH3:4].[CH3:5][C:6]([O:9][C:10]([NH:12][CH:13]([C:20]([OH:22])=O)[CH2:14][C:15]1[N:19]=[CH:18][S:17][CH:16]=1)=[O:11])([CH3:8])[CH3:7]>>[C:6]([O:9][C:10](=[O:11])[NH:12][C@H:13]([C:20](=[O:22])[N:3]([CH3:4])[CH3:2])[CH2:14][C:15]1[N:19]=[CH:18][S:17][CH:16]=1)([CH3:5])([CH3:7])[CH3:8]

参加物

3

反応物 2

HCID 10473Dimethylamine, hydrochlorideHCID 145403222-((tert-Butoxycarbonyl)amino)-3-(thiazol-4-yl)propanoic acid

生成物 1

HCID 54383962(s)-(1-Dimethylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester

実験手順

Dimethylamine hydrochloride (1.2 mmol) and Boc-L-3-(4-thiazolyl)alanine (1.0 mmol) were coupled according to Procedure A (0-25° C. reaction temperature) and the product purified by chromatography on silica gel eluted with 1-16% ethanol In dichloromethane containing 0.5% ammonium hydroxide. Yield 124 mg, 41%.

後処理

  1. customthe product purified by chromatography on silica gel
  2. washeluted with 1-16% ethanol In dichloromethane containing 0.5% ammonium hydroxide

出典と根拠

ORDレコード
ord-d18d013b226a446b9def77135af71ba0
出典データセット
uspto-grants-2001_08
特許番号
US06277877B1

関連ノート

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