Malononitrile → Dihydro-2H-pyran-4,4(3H)-dicarbonitrile

HRID 651735

反応式

HRID 651735 の反応式
Cl[CH:2](Cl)[CH2:3][O:4][CH2:5][CH:6](Cl)Cl.[C:10](#[N:14])[CH2:11][C:12]#[N:13].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[O:4]1[CH2:5][CH2:6][C:11]([C:10]#[N:14])([C:12]#[N:13])[CH2:2][CH2:3]1

参加物

5

反応物 3

HCID 8010MalononitrileHCID 11430Potassium CarbonateHCID 623831,1'-Oxybis(2,2-dichloroethane)

生成物 1

HCID 14537194Dihydro-2H-pyran-4,4(3H)-dicarbonitrile

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

According to Flowchart B dichloroethyl ether (7) and malononitrile (8) are reacted with potassium carbonate in acetonitrile at reflux, giving tetrahydro-4H-pyran-4,4-dicarbonitrile (9) which is then reacted with 1N borane in tetrahydrofuran followed by treatment with hydrochloric acid, giving tetrahydro-4H-pyran-4,4-dimethanamine dihydrochloride (10) which is then reacted with sodium acetate and potassium tetrachloroplatinate in water, giving the product (11).

後処理

  1. temperatureat reflux

出典と根拠

ORDレコード
ord-9feac1c7d68d41e1a05a382e62012bcf
出典データセット
uspto-grants-2001_08
特許番号
US06281365B1

関連ノート

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