Methanesulfonamide → HCID 20198291、化合物

HRID 652034

反応式

HRID 652034 の反応式
Cl.[CH3:2][Si:3]([CH3:29])([CH3:28])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1.[CH3:30][S:31]([NH2:34])(=[O:33])=[O:32]>N1C=CC=CC=1>[CH3:2][Si:3]([CH3:29])([CH3:28])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:34][S:31]([CH3:30])(=[O:33])=[O:32])=[O:24])=[CH:21][CH:20]=1

参加物

4

反応物 2

HCID 72879MethanesulfonamideHCID 201982304-[14-(Trimethylsilyl)tetradecylamino]benzoyl chloride hydrochloride

生成物 1

HCID 20198291HCID 20198291、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of 12.3 g. of 4-[14-(trimethylsilyl)tetradecylamino]benzoyl chloride hydrochloride and 2.8 g. of methanesulfonamide in 150 ml. of pyridine is stirred at reflux for 2 hours and then evaporated in vacuo. The residue is partitioned between water and diethyl ether, the aqueous layer acidified with 1N hydrochloric acid, and the organic layer separated, dried with magnesium sulfate and evaporated. Crystallization of the residue affords the product as a white solid.

後処理

  1. temperatureat reflux for 2 hours
  2. customevaporated in vacuo
  3. customThe residue is partitioned between water and diethyl ether
  4. customthe organic layer separated
  5. dry with materialdried with magnesium sulfate
  6. customevaporated
  7. customCrystallization of the residue

出典と根拠

ORDレコード
ord-ae62468ef3c546e7b5459000a2be9856
出典データセット
uspto-grants-1987_06
特許番号
US04670421

関連ノート

読み込み中…