Chloride → N-(4-methylfurazan-3-yl)cyclopropanecarboxamide

HRID 652384ノート

反応式

HRID 652384 の反応式
[CH3:1][C:2]1[C:3]([NH2:7])=[N:4][O:5][N:6]=1.C(OCC)C.[Cl-].[CH:14]1([C:17](O)=[O:18])[CH2:16][CH2:15]1>N1C=CC=CC=1>[CH3:1][C:2]1[C:3]([NH:7][C:17]([CH:14]2[CH2:16][CH2:15]2)=[O:18])=[N:4][O:5][N:6]=1

参加物

6

反応物 4

HCID 312ChlorideHCID 3283Diethyl EtherHCID 15655Cyclopropanecarboxylic acidHCID 286743-Amino-4-methylfurazan

生成物 1

HCID 20197118N-(4-methylfurazan-3-yl)cyclopropanecarboxamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

5 g (about 0.05 moles) of 4-methyl-3-aminofurazan, 50 ml of ethyl ether and 4 ml of pyridine are then loaded into a 100 ml glass reactor. This is cooled to a temperature of from 0° to 10° C. and 5 ml (0.06 moles) of the chloride of cyclopropanecarboxylic acid are added under agitation. Heating is then carried out under reflux for about one hour. After cooling of the reaction mass, the ether is evaporated and the residual solid is transferred into about 100 ml of water. Slight heating is effected for about 30 minutes and then the mass is cooled and filtered, the solid being washed with water. The solid obtained is dried in an oven at 90° C.

後処理

  1. additionare added under agitation
  2. temperatureHeating
  3. temperatureunder reflux for about one hour
  4. temperatureAfter cooling of the reaction mass
  5. customthe ether is evaporated
  6. temperatureSlight heating
  7. temperaturethe mass is cooled
  8. filtrationfiltered
  9. washthe solid being washed with water
  10. customThe solid obtained
  11. customis dried in an oven at 90° C.

出典と根拠

ORDレコード
ord-6e1ecb825e39456ea89633c4f4a20720
出典データセット
uspto-grants-1987_06
特許番号
US04671818

反応ノート

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