Thionyl Chloride → 2-Methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoyl chloride

HRID 652757ノート

反応式

HRID 652757 の反応式
[CH3:1][O:2][C:3]1[C:11]([CH:12]([CH3:14])[CH3:13])=[CH:10][C:9]([S:15](=[O:18])(=[O:17])[NH2:16])=[C:8]([CH3:19])[C:4]=1[C:5](O)=[O:6].S(Cl)([Cl:22])=O>CN(C)C=O.C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[C:11]([CH:12]([CH3:14])[CH3:13])=[CH:10][C:9]([S:15](=[O:18])(=[O:17])[NH2:16])=[C:8]([CH3:19])[C:4]=1[C:5]([Cl:22])=[O:6]

参加物

5

反応物 2

HCID 24386Thionyl Chloride2 回HCID 201968382-Methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoic acid

生成物 1

HCID 201968202-Methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6212Chloroform溶媒

実験手順

72 g of 2-methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoic acid (0.25 mole), 250 ml of chloroform, 23 ml of thionyl chloride and 3 drops of dimethylformamide are placed in a 1 liter flask fitted with an agitator and a condenser. The mixture is heated to reflux for 1.5 hours, then 18 ml of thionyl chloride is added and the reflux is continued for 1.5 hours. The solids dissolve completely.

後処理

  1. customfitted with an agitator and a condenser
  2. temperatureThe mixture is heated
  3. temperatureto reflux for 1.5 hours
  4. dissolutionThe solids dissolve completely

出典と根拠

ORDレコード
ord-d2d56191e7bf4e59bfa653ea03ba0440
出典データセット
uspto-grants-1987_06
特許番号
US04673686

反応ノート

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