Putrescine → HCID 54039930、化合物

HRID 652954

反応式

HRID 652954 の反応式
NCCCCN.C(O)(=O)CCCCCCC/C=C\C/C=C\C/C=C\CC.[CH3:27][O:28][C:29]1[CH:30]=[C:31]([CH:42]=[CH:43][CH:44]=[CH:45][C:46]([NH:48][CH2:49][CH2:50][CH2:51][CH2:52][NH:53][C:54](=[O:72])[CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH:62]=[CH:63][CH2:64][CH:65]=[CH:66][CH2:67][CH:68]=[CH:69][CH2:70][CH3:71])=[O:47])[CH:32]=[CH:33][C:34]=1[O:35]COCCOC.O1CCOCC1CC(O)=O.O>O1CCCC1>[CH3:27][O:28][C:29]1[CH:30]=[C:31]([CH:42]=[CH:43][CH:44]=[CH:45][C:46]([NH:48][CH2:49][CH2:50][CH2:51][CH2:52][NH:53][C:54](=[O:72])[CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH:62]=[CH:63][CH2:64][CH:65]=[CH:66][CH2:67][CH:68]=[CH:69][CH2:70][CH3:71])=[O:47])[CH:32]=[CH:33][C:34]=1[OH:35]

参加物

6

反応物 4

HCID 1045PutrescineHCID 5280934Linolenic AcidHCID 53812474HCID 53812474、化合物HCID 69202663HCID 69202663、化合物

生成物 1

HCID 54039930HCID 54039930、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution fo 880 mg (10 mmol) of 1,4-diaminobutane in tetrahydrofuran (20 ml) was added in an argon atmosphere a solutin fo 410 mg (1 mmol) of N-{5-(3-methoxy-4-β-methoxyethoxymethoxyphenyl)-2,4-pentadienoyl}-2-thiothiazolidine in tetrahydrofuran (10 ml) at room temperature over 30 min. The mixture was treated in the same way as in Example 3 to react with 390 mg (1.05 mmol) of α-linolenic acid thiazolidinethionamide. The reaction product was treated in the same way as in Example 3 to hydrolyze N-{5-(3-methoxy-4-β-methoxyethoxymethoxyphenyl)-2,4-pentadienoyl}-N'-9,12,15-octadecatrieneo yl-1,4-diaminobutane with 1,4-dioxane - acetic acid-water (5:4:1). The reaction product was treated in the same way as in Example 3 to give 195 mg (0.35 mmol) of N-{5-(3-methoxy-4-hydroxyphenyl)-2,4-pentadienoyl}-N'- 9,12,15-octadecatrienoyl-1,4-diaminobutane. Spectrophotometric data of the product support the structure shown below. ##STR31##

後処理

  1. additionwas added in an argon atmosphere a solutin
  2. customat room temperature
  3. customover 30 min
  4. additionThe mixture was treated in the same way as in Example 3
  5. additionThe reaction product was treated in the same way as in Example 3
  6. additionThe reaction product was treated in the same way as in Example 3

出典と根拠

ORDレコード
ord-1159ac9b361b47d59daca87cc3e75dbb
出典データセット
uspto-grants-1987_06
特許番号
US04673684

関連ノート

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