Ethyl Acetate → L-Phenylalanine

HRID 65321

反応式

HRID 65321 の反応式
C[O:2][C:3](=[O:13])[CH:4]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[NH2:5].C(OCC)(=O)C.[OH-].[Na+]>O>[NH2:5][C@H:4]([C:3]([OH:13])=[O:2])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 75737DL-Phenylalanine, methyl ester

生成物 1

HCID 6140L-Phenylalanine収率 98%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 1.15 grams of D,L-phenylalanine methyl ester in 2.5 milliliters of water was added to 5.0 milliliters of ethyl acetate. The pH was adjusted to 6.5 with 2.5 milliliters of sodium hydroxide. Two milligrams of chymotrypsin was added and the reaction was stirred gently at room temperature. A white precipitate appeared after 1.5 hours. The precipitate was isolated after 2 hours yielding 0.22 grams with an optical rotation equivalent to 98% pure L-phenylalanine.

後処理

  1. additionTwo milligrams of chymotrypsin was added
  2. customThe precipitate was isolated after 2 hours

出典と根拠

ORDレコード
ord-a1998eaeb8504d398dcc88c0ffe4372b
出典データセット
uspto-grants-1986_09
特許番号
US04613691

関連ノート

読み込み中…