Hydroquinone → N-Octyl-beta-alanine

HRID 65420

反応式

HRID 65420 の反応式
[CH2:1]([NH2:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C1(C=CC(O)=CC=1)O.[C:18]([OH:22])(=[O:21])[CH:19]=[CH2:20].[OH-].[Na+]>CC(C)=O.CO>[CH2:1]([NH:9][CH2:20][CH2:19][C:18]([OH:22])=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

参加物

7

反応物 4

HCID 785HydroquinoneHCID 6581Acrylic AcidHCID 8143OctylamineHCID 14798Sodium Hydroxide

生成物 1

HCID 13765821N-Octyl-beta-alanine収率 78%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 887Methanol溶媒

実験手順

To a mixture of n-octylamine (516 g, 4.0 mols), hydroquinone (200 mg) and methanol (400 ml), acrylic acid (144 g, 2.0 mols) was added dropwise with stirring while cooling with ice. After addition, the mixture was refluxed while heating for 4 hours. After cooled to room temperature, NaOH (80 g, 2.0 mols) was added. The reaction mixture was despersed in 6 liters of acetone, and filtration and drying were carried out to obtain the Na salt of N-n-octyl-β-alanine as white crystals having a melting point (dec.) of 242° C. (349 g Yield: 78%).

後処理

  1. additionwas added dropwise
  2. temperaturewhile cooling with ice
  3. additionAfter addition
  4. temperaturethe mixture was refluxed
  5. temperaturewhile heating for 4 hours
  6. filtrationfiltration
  7. customdrying

出典と根拠

ORDレコード
ord-5e8802d8235240cab6cb20b4167dd222
出典データセット
uspto-grants-1986_09
特許番号
US04614699

関連ノート

読み込み中…