Monobasic potassium phosphate → Ribavirin

HRID 65427

反応式

HRID 65427 の反応式
[NH:1]1[CH:5]=[N:4][C:3]([C:6]([NH2:8])=[O:7])=[N:2]1.[C@@H:9]1(N2C3N=CN=C(O)C=3N=C2)[O:17][C@H:14]([CH2:15][OH:16])[C@@H:12]([OH:13])[C@H:10]1[OH:11].P([O-])(O)(O)=O.[K+]>>[CH:5]1[N:1]([C@@H:9]2[O:17][C@H:14]([CH2:15][OH:16])[C@@H:12]([OH:13])[C@H:10]2[OH:11])[N:2]=[C:3]([C:6]([NH2:8])=[O:7])[N:4]=1

参加物

4

反応物 3

HCID 516951Monobasic potassium phosphateHCID 178513825HCID 178513825、化合物HCID 178521066(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxypurin-9-yl)oxolane-3,4-diol

生成物 1

HCID 37542Ribavirin収率 74.88%

実験手順

After completion of the cultivation, the cells were collected by centrifugation, washed and a sterilized water was added thereto to obtain 250 ml of a cell suspension. Into 750 ml of an aqueous solution containing 66.7 mM 1,2,4-triazole-3-carboxamide, 66.7 mM inosine and 100 mM monopotassium dihydrogen phosphate was added 250 ml of the above cell suspension, and the reaction was carried out at 60° C. for 24 hours (ribavirin yield: 74.88%).

出典と根拠

ORDレコード
ord-5d3d90781b2745c6ba6d29a8baff8dd4
出典データセット
uspto-grants-1986_09
特許番号
US04614719

関連ノート

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