4-Hydroxybenzaldehyde → 4-(2-Butoxyethoxy)benzaldehyde

HRID 654414ノート

反応式

HRID 654414 の反応式
Br[CH2:2][CH2:3][O:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[O:15])=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:5]([O:4][CH2:3][CH2:2][O:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[O:15])=[CH:12][CH:11]=1)[CH2:6][CH2:7][CH3:8]

参加物

5

反応物 3

HCID 1264-HydroxybenzaldehydeHCID 11430Potassium CarbonateHCID 1387612-Butoxyethyl bromide

生成物 1

HCID 198872374-(2-Butoxyethoxy)benzaldehyde収率 64%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Nine grams (0.05 mole) of 1-bromo-2-butoxy-ethane and 6.1 grams (0.05 mole) of 4-hydroxybenzaldehyde were dissolved in 75 mls. of acetonitrile. Into the mixture were added 13.8 grams (0.1 mole) of finely ground potassium carbonate and the resulting reaction mixture was stirred under reflux for ten hours. The reaction mixture was allowed to cool, was filtered, washed with acetonitrile and evaporated to an amber oily product. The product was passed through a silica gel chromatographic column for recovery of a colorless oil (64% yield) having the following structure: ##STR20##

後処理

  1. customthe resulting reaction mixture
  2. temperatureunder reflux for ten hours
  3. temperatureto cool
  4. filtrationwas filtered
  5. washwashed with acetonitrile
  6. customevaporated to an amber oily product

出典と根拠

ORDレコード
ord-713a336d939e408ebc21ec034e7fddc7
出典データセット
uspto-grants-1992_07
特許番号
US05132041

反応ノート

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