4,4'-Dihydroxybiphenyl → HCID 19887240、化合物

HRID 654417ノート

反応式

HRID 654417 の反応式
Br[CH2:2][CH2:3][O:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:5]([O:4][CH2:3][CH2:2][O:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)=[CH:14][CH:15]=1)[CH2:6][CH2:7][CH3:8]

参加物

5

反応物 3

HCID 71124,4'-DihydroxybiphenylHCID 11430Potassium CarbonateHCID 1387612-Butoxyethyl bromide

生成物 1

HCID 19887240HCID 19887240、化合物収率 20%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

One gram (5.5 millimoles) of 1-bromo-2-butoxyethane was combined with 5.5 grams (30 millimoles) of 4,4'-dihydroxybiphenyl in 75 mls. of acetonitrile. To the reaction mixture were added 8.3 grams (60 millimoles) of finely ground potassium carbonate. Stirring was begun and the reaction mixture was brought to reflux and maintained for 48 hours. The reaction product was filtered, washed with acetonitrile and evaporated for removal of solvent. The product was passed through a silica gel chromatographic column using dichloromethane eluent, for recovery of 0.25 gram (20% yield) of a biphenol ether compound having the following formula confirmed by TLC, IR and mass spectral analyses: ##STR26##

後処理

  1. temperatureto reflux
  2. temperaturemaintained for 48 hours
  3. filtrationThe reaction product was filtered
  4. washwashed with acetonitrile
  5. customevaporated for removal of solvent

出典と根拠

ORDレコード
ord-cc03d9841e7b41ffb2eb7a7d00bd189c
出典データセット
uspto-grants-1992_07
特許番号
US05132041

反応ノート

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