2-Thiophenecarboxaldehyde → HCID 85316399、化合物

HRID 654568

反応式

HRID 654568 の反応式
[CH:1]1[CH:5]=C(C=O)[S:3][CH:2]=1.ClCC(O[CH:13]([CH3:15])[CH3:14])=O.[OH-:16].[Na+].Cl.[NH2:19]O>O.ClCCl>[S:3]1[CH:2]=[CH:1][CH:5]=[C:15]1[CH2:13][CH:14]=[N:19][OH:16]

参加物

7

反応物 4

HCID 73642-ThiophenecarboxaldehydeHCID 7759Isopropyl chloroacetateHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 85316399HCID 85316399、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 6344Dichloromethane溶媒

反応条件

温度
50 °C

実験手順

A mixture of 168 g of 2-thienylcarboxaldehyde and 12.9 g of isopropyl chloroacetate is then introduced over 30 minutes. The solution is stirred for 25 minutes at this temperature and 257 g of an aqueous solution of sodium hydroxide at a concentration of 35% are then added over 30 minutes. The mixture is stirred at 50° C. for 2 hours, is cooled to 25° C. and 161.5 g of hydroxylamine hydrochloride dissolved in 200 ml of water are then introduced over 30 minutes. The mixture is kept stirred for 30 minutes and is then added to 1.5 l of water and 1.5 l of dichloromethane.

後処理

  1. additionis then introduced over 30 minutes
  2. additionare then added over 30 minutes
  3. temperatureis cooled to 25° C.
  4. additionare then introduced over 30 minutes
  5. stirringThe mixture is kept stirred for 30 minutes

出典と根拠

ORDレコード
ord-2757e7a18a954c8396c2cb67dba87d3d
出典データセット
uspto-grants-1992_07
特許番号
US05132435

関連ノート

読み込み中…