2-Methoxy-1,4-Naphthoquinone → 2-Methoxynaphthalene-1,4-diol

HRID 654847

反応式

HRID 654847 の反応式
[CH3:1][O:2][C:3]1[C:4](=[O:14])[C:5]2[C:10]([C:11](=[O:13])[CH:12]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[H][H]>O1CCCC1.[Pd]>[CH3:1][O:2][C:3]1[CH:12]=[C:11]([OH:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]=1[OH:14]

参加物

5

反応物 2

HCID 168712-Methoxy-1,4-NaphthoquinoneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 125635442-Methoxynaphthalene-1,4-diol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 2-methoxy-1,4-naphthoquinone (20.0 g) in tetrahydrofuran (150 mL) was hydrogenated at atmospheric pressure over Pd-C (10%, 0.5 g) until the calculated amount of hydrogen was absorbed, approximately 4 hours. Filtering off the catalyst under an atmosphere of nitrogen gave a solution of the desired product, which was used as such without isolation of the product as the starting material in Examples 1, 2 and 3, infra. Alternatively, the solvent is removed under reduced pressure and the residue recrystallized from diethyl ether/pentane, affording 2-methoxy-1,4-dihydroxynaphthalene.

後処理

  1. customwas absorbed, approximately 4 hours
  2. filtrationFiltering off the catalyst under an atmosphere of nitrogen

出典と根拠

ORDレコード
ord-20da1a44278c47c0ae2d9953ff17eaea
出典データセット
uspto-grants-1992_07
特許番号
US05134161

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