Hydrochloric Acid → HCID 85526988、化合物

HRID 65488ノート

反応式

HRID 65488 の反応式
[C:1]1([CH2:7][CH:8]=[N:9][OH:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClCl.ClC1(CC=NO)C=CC=CC1.[CH3:24][C:25]([CH3:28])([O-:27])[CH3:26].[K+].Cl>C(Cl)(Cl)Cl.C(O)(C)(C)C>[C:25]([O:27][C:8](=[N:9][OH:10])[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)([CH3:28])([CH3:26])[CH3:24]

参加物

8

反応物 5

HCID 313Hydrochloric AcidHCID 24526ChlorineHCID 99748PhenylacetaldoximeHCID 23665647Potassium tert-butoxide2 回HCID 867410451-Chlorophenyl acetaldehyde oxime

生成物 1

HCID 85526988HCID 85526988、化合物

試薬・触媒・溶媒 2

HCID 6212Chloroform溶媒HCID 6386tert-Butanol溶媒

実験手順

Using the procedure of Example I, phenyl acetaldehyde oxime in chloroform is reacted with chlorine gas introduced at -5° to 0° C. To the resulting solution of 1-chlorophenyl acetaldehyde oxime is added dropwise with stirring a solution of potassium t-butoxide in t-butanol. The reaction is allowed to go to completion and any residual potassium t-butoxide is neutralized with hydrogen chloride gas. The precipitated potassium chloride is removed by filtration, and the filtrate concentrated under reduced pressure to provide the desired 1-(t-butoxy)-2-phenyl acetaldehyde oxime.

後処理

  1. additionintroduced at -5° to 0° C
  2. customThe precipitated potassium chloride is removed by filtration
  3. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-4877adffe60f4315972688612a661cb9
出典データセット
uspto-grants-1986_09
特許番号
US04614813

反応ノート

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