Thionyl Chloride → 4-(2-Chloroethyl)-1,2-dimethoxybenzene

HRID 655597

反応式

HRID 655597 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12]O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].S(Cl)([Cl:16])=O>C(Cl)(Cl)Cl>[Cl:16][CH2:12][CH2:11][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 819113,4-Dimethoxyphenethyl alcohol

生成物 1

HCID 30153594-(2-Chloroethyl)-1,2-dimethoxybenzene

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

The reaction mixture of 2-(3,4-dimethoxyphenyl)ethanol (6.0 g, 32.8 mmol) and thionyl chloride (19 g, 164 mmol) in chloroform (20 mL) was stirred at reflux for 4 h, concentrated, and partitioned between water and ethyl acetate. The organic layer was washed with NaHCO3 and brine, dried over anhydrous sodium sulfate, and concentrated to afford 4-(2-chloroethyl)-1,2-dimethoxybenzene (K) quantitatively (6.6 g).

後処理

  1. temperatureat reflux for 4 h
  2. concentrationconcentrated
  3. custompartitioned between water and ethyl acetate
  4. washThe organic layer was washed with NaHCO3 and brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-9fe038c086794b04aa89d880c5f58bba
出典データセット
uspto-grants-2011_12
特許番号
US08071602B2

関連ノート

読み込み中…