Water → HCID 66798076、化合物

HRID 655919ノート

反応式

HRID 655919 の反応式
[Cl:1][C:2]1[C:3]([CH2:12][C:13]#[N:14])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH:15](C)(C)[C:16]([O-])=O.[K+].C(I)C.O>C1COCC1.C(OCC)(=O)C>[Cl:1][C:2]1[C:3]([CH:12]([CH2:15][CH3:16])[C:13]#[N:14])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

参加物

7

反応物 4

HCID 962WaterHCID 6340IodoethaneHCID 162272722-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrileHCID 23677462Potassium isobutyrate

生成物 1

HCID 66798076HCID 66798076、化合物

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

199 g (0.9 mol) of 3 of [3-chloro-5-(trifluoromethyl)-2-pyridinyl]acetonitrile are dissolved in 3 L of THF at −5° C. A solution of 106 g (0.945 mol) of potassium tertbutanoate in 0.6 L of THF is slowly added to the reaction medium. After 2 H, 147 g (0.945 mol) of ethyl iodide is added dropwise to the reaction mixture which is stirred overnight at room temperature. 3 L of water and 2 L of ethyl acetate are added to the reaction mixture, after separation, the aqueous phase is extracted twice with 500 mL of ethyl acetate.

後処理

  1. customafter separation
  2. extractionthe aqueous phase is extracted twice with 500 mL of ethyl acetate

出典と根拠

ORDレコード
ord-cdd4397d0e174c85a61695ec06ae595b
出典データセット
uspto-grants-2011_12
特許番号
US08071627B2

反応ノート

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