Methanol → 2-Hydroxy-6-methylpyridine-3-carbaldehyde

HRID 657161ノート

反応式

HRID 657161 の反応式
[OH:1][CH2:2][C:3]1[C:4](=[O:10])[NH:5][C:6]([CH3:9])=[CH:7][CH:8]=1.C1COCC1.CO>C(Cl)Cl.O=[Mn]=O>[CH3:9][C:6]1[NH:5][C:4](=[O:10])[C:3]([CH:2]=[O:1])=[CH:8][CH:7]=1

参加物

6

反応物 3

HCID 887MethanolHCID 8028TetrahydrofuranHCID 202160783-(Hydroxymethyl)-6-methylpyridin-2(1H)-one

生成物 1

HCID 127224622-Hydroxy-6-methylpyridine-3-carbaldehyde収率 101%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6344Dichloromethane溶媒

反応条件

温度
57 °C

実験手順

3-(hydroxymethyl)-6-methyl-2(1H)-pyridinone (2.0 g, 13 mmol) was dissolved in CH2Cl2(80 mL), THF (80 mL) and MeOH (5 mL), MnO2 (3.7 g, 43 mmol) was added. The reaction mixture was heated at 57° C. for 18 hours. The reaction was filtered through a pad of Celite® and concentrated to give a solid (1.8 g, 90%). LCMS (ES+) m/z 138 (MH+).

後処理

  1. filtrationThe reaction was filtered through a pad of Celite®
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-38e5c289d77b47e98b517c9b86820670
出典データセット
uspto-grants-2011_12
特許番号
US08071592B2

反応ノート

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