m-Chloroperbenzoic acid → 4-(4-Methoxyphenyl)pyridine 1-oxide

HRID 657664

反応式

HRID 657664 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.ClC1C=CC=C(C(OO)=[O:23])C=1>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[CH:11][N+:12]([O-:23])=[CH:13][CH:14]=2)=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 6038134-(4-Methoxyphenyl)pyridine

生成物 1

HCID 576720264-(4-Methoxyphenyl)pyridine 1-oxide収率 91.1%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of 4-(4-methoxyphenyl)pyridine (5.68 g) and metachloroperbenzoic acid (70%, 11.34 g) in chloroform is stirred for 2.5 hours at room temperature, concentrated under reduced pressure and purified by chromatography over silica gel (eluent dichloromethane/methanol from 100/0 to 90/10) to give 5.62 g of 4-(4-methoxyphenyl)pyridine 1-oxide used without further purification.

後処理

  1. concentrationconcentrated under reduced pressure
  2. custompurified by chromatography over silica gel (eluent dichloromethane/methanol from 100/0 to 90/10)

出典と根拠

ORDレコード
ord-f738d9a8a70f4f0b924fb6511fffda6b
出典データセット
uspto-grants-2011_12
特許番号
US08076329B2

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