Propylenediamine → N,N'-bis-(2-hydroxybenzyl)-propylenediamine

HRID 65831

反応式

HRID 65831 の反応式
[CH:1](=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[CH2:10]([NH2:14])[CH:11]([NH2:13])[CH3:12]>C(O)(C)C.[Pt]>[OH:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[CH2:1][NH:14][CH2:10][CH:11]([NH:13][CH2:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[OH:4])[CH3:12]

参加物

5

反応物 2

HCID 6567PropylenediamineHCID 6998Salicylaldehyde

生成物 1

HCID 15493877N,N'-bis-(2-hydroxybenzyl)-propylenediamine収率 87.5%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 3776Isopropanol溶媒

実験手順

84.6 g of a bisazomethine prepared from 2 moles of salicylaldehyde and 1 mol of propylenediamine and having a melting point of 57°-58° C. are hydrogenated for 3 hours in 340 ml of isopropanol in an autoclave in the presence of 1.20 g of 5% platinum/charcoal at 45° C. and under a pressure of 50-60 atmospheres. The product crystallises out at room temperature and is dissolved by boiling, with the addition of a further 660 ml of isopropanol. The catalyst is filtered off and the diamine crystallises out on cooling. The crystals are collected by filtration, washed and dried, yielding 75.1 g of N,N'-bis-(2-hydroxybenzyl)-propylenediamine (87.5% of theory); melting point 109°-110° C.

後処理

  1. customThe product crystallises out at room temperature
  2. dissolutionis dissolved
  3. additionby boiling, with the addition of a further 660 ml of isopropanol
  4. filtrationThe catalyst is filtered off
  5. customthe diamine crystallises out
  6. temperatureon cooling
  7. filtrationThe crystals are collected by filtration
  8. washwashed
  9. customdried

出典と根拠

ORDレコード
ord-2c4702a80baf44e485c0b735f74f5f11
出典データセット
uspto-grants-1978_12
特許番号
US04129556

関連ノート

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