1,2-Dibromoethane → 2-Methyloct-1-en-6-yn-3-ol

HRID 65907

反応式

HRID 65907 の反応式
C(Br)CBr.Br[C:6]([CH3:8])=[CH2:7].[CH:9](=[O:15])[CH2:10][CH2:11][C:12]#[C:13][CH3:14].[Cl-].[NH4+]>O1CCCC1>[CH3:8][C:6]([CH:9]([OH:15])[CH2:10][CH2:11][C:12]#[C:13][CH3:14])=[CH2:7]

参加物

6

反応物 4

HCID 78391,2-DibromoethaneHCID 112022-BromopropeneHCID 25517Ammonium ChlorideHCID 10975410Hex-4-ynal2 回

生成物 1

HCID 126539292-Methyloct-1-en-6-yn-3-ol収率 85%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Magnesium (14.4g, 0.6g atom) was dried in a 250ml flask fitted with reflux condenser, mechanical stirrer and addition funnel. After initiation of reaction under dry N2 with about one ml ethylene dibromide in 70ml tetrahydrofuran, 36.0g (0.30 mole) 2-bromopropene was added dropwise at such a rate as to maintain reflux without external heating. The Grignard solution was then stirred until it cooled to room temperature (30 minutes-1 hour). It was then cooled further to -15° in ice-salt, and the total crude 4-hexynal from part (c) above was added dropwise over 15 minutes. The reaction mixture was stirred for 2 hours at room temperature, saturated ammonium chloride solution was added and the product was extracted with ether. There was obtained 23.50g of 2-methyloct-1-en-6-yn-3-ol (85%, based on 4-methyl hexynoate) as a pale yellow oil.

後処理

  1. dry with materialMagnesium (14.4g, 0.6g atom) was dried in a 250ml flask
  2. customfitted
  3. temperaturewith reflux
  4. additioncondenser, mechanical stirrer and addition funnel
  5. additionwas added dropwise at such a rate as
  6. temperatureto maintain
  7. temperaturereflux without external heating
  8. stirringThe reaction mixture was stirred for 2 hours at room temperature
  9. extractionthe product was extracted with ether

出典と根拠

ORDレコード
ord-b24878b02837494690d9a7b9ee9fa0c1
出典データセット
uspto-grants-1978_12
特許番号
US04129599

関連ノート

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