Diisopropylethylamine → 3-{3-[(5-Benzoyl-furan-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester

HRID 659097

反応式

HRID 659097 の反応式
[C:1]([C:9]1[O:13][C:12]([C:14]([OH:16])=O)=[CH:11][CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:17]([O:19][C:20](=[O:30])[CH:21]=[CH:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([NH2:29])[CH:24]=1)[CH3:18].CCN(C(C)C)C(C)C>CN(C=O)C>[CH2:17]([O:19][C:20](=[O:30])[CH:21]=[CH:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([NH:29][C:14]([C:12]2[O:13][C:9]([C:1](=[O:8])[C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:10][CH:11]=2)=[O:16])[CH:24]=1)[CH3:18]

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 978253-Aminocinnamic acid ethyl esterHCID 28772555-Benzoylfuran-2-carboxylic acid

生成物 1

HCID 684126103-{3-[(5-Benzoyl-furan-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Acid (9) (48 mg, 0.22 mmol) was coupled to aniline (2) (43 mg, 0.22 mmol) using Method B, except that DIPEA (57 mg, 0.44 mmol) and DMF (0.5 mL) were used. The crude product was purified by preparative HPLC to give the title compound. Yield: 28 mg; LC-MS tr 41.54 min; MS (ES+) m/z 389 (M+H)

後処理

  1. customThe crude product was purified by preparative HPLC

出典と根拠

ORDレコード
ord-1a215cd9103e447a89e05584481b6c9e
出典データセット
uspto-grants-2011_12
特許番号
US08080567B2

関連ノート

読み込み中…