Sodium Hydroxide → 5-Phenylfuran-2-carboxylic acid

HRID 659114

反応式

HRID 659114 の反応式
[C:1]1([C:7]2[O:11][C:10]([CH:12]=[O:13])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:14].[Na+]>[N+]([O-])([O-])=O.[Ag+]>[C:1]1([C:7]2[O:11][C:10]([C:12]([OH:14])=[O:13])=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 14798Sodium Hydroxide2 回HCID 27694205-Phenyl-2-furaldehyde

生成物 1

HCID 7362555-Phenylfuran-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 24470Silver Nitrate触媒

反応条件

温度
60 °C

実験手順

To 5-phenyl-2-furaldehyde (35) (690 mg, 4.01 mmol) was added solid NaOH (176 mg, 4.40 mmol) then 10% NaOH solution (6.2 mL). Silver nitrate (680 mg, 4.00 mmol) was added and the reaction mixture heated to 60° C. for 4.5 hours then cooled to ambient temperature. The reaction mixture was then filtered and washed with water. The filtrate was acidified to pH 2 using 2N HCl and the precipitated product filtered and dried to give the title compound.

後処理

  1. temperaturethen cooled to ambient temperature
  2. filtrationThe reaction mixture was then filtered
  3. washwashed with water
  4. filtrationthe precipitated product filtered
  5. customdried

出典と根拠

ORDレコード
ord-fe5a9621d48b45708e5f897cbdb23907
出典データセット
uspto-grants-2011_12
特許番号
US08080567B2

関連ノート

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