Acetonitrile → HCID 178434074、化合物

反応式

[Cl:1][C:2]1[C:17]([O:18][CH2:19][CH2:20][N:21]2[CH:25]=[N:24][N:23]=[N:22]2)=[C:16]([Cl:26])[CH:15]=[CH:14][C:3]=1[C:4]([O:6]C1N(C)N=C(C)C=1)=O.C([N:29]([CH2:32][CH3:33])[CH2:30]C)C.CC(C)([OH:38])C#N.[C:40](#[N:42])[CH3:41]>>[Cl:1][C:2]1[C:17]([O:18][CH2:19][CH2:20][N:21]2[CH:25]=[N:24][N:23]=[N:22]2)=[C:16]([Cl:26])[CH:15]=[CH:14][C:3]=1[C:4]([C:33]1[C:40]([CH3:41])=[N:42][N:29]([CH3:30])[C:32]=1[OH:38])=[O:6]

参加物

反応物 4

HCID 6342Acetonitrile

HCID 6406Acetone Cyanohydrin

HCID 8471Triethylamine

HCID 592816475-{2,4-Dichloro-3-[2-(1H-tetrazol-1-yl)ethyloxy]-benzoyloxy}-1,3-dimethylpyrazole

生成物 1

HCID 178434074HCID 178434074、化合物

実験手順

5-{2,4-Dichloro-3-[2-(1H-tetrazol-1-yl)ethyloxy]-benzoyloxy}-1,3-dimethylpyrazole (0.65 g) was dissolved in acetonitrile (10 ml), triethylamine (0.33 g) and acetone cyanohydrin (40 mg) were added thereto and the mixture was stirred at room temperature for 12 hours. The solvent was distilled off, acidified by the addition of diluted hydrochloric acid and extracted with ethyl acetate (150 ml). The organic layer was washed with saturated brine and dried with anhydrous magnesium sulfate. Ethyl acetate was distilled off to obtain objective 4-{2,4-dichloro-3-[2-(1H-tetrazol-1-yl)ethoxy]benzoyl}-1,3-dimethyl-5-hydroxy-pyrazole (0.59 g).