Methyl iodide → HCID 178488729、化合物

HRID 66016

反応式

HRID 66016 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]3[CH:17]=2)=[CH:5][CH:4]=1.[CH3:18][I:19]>C(#N)C>[I-:19].[CH3:18][N+:10]1[C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[CH:17][N:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=12

参加物

4

反応物 2

HCID 6328Methyl iodide2 回HCID 6949632-(4-Methoxyphenyl)imidazo[1,2-a]pyridine

生成物 1

HCID 178488729HCID 178488729、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To 2.23 g. of 2-(4-methoxyphenyl)imidazo[1,2-a]pyridine in 50 ml. of acetonitrile is added 2.84 g. of methyl iodide, and the resulting reaction mixture refluxed for 3 hrs. Additional methyl iodide (2 ml.) is added and reflux continued for one hour. The solids which precipitate on cooling are filtered and partially dissolved in boiling isopropanol and filtered. The isopropanol filtrate is cooled and treated with diethyl ether. The crystallized product is filtered and dried to give 1.03 g., m.p. 194-196° C.

後処理

  1. temperaturerefluxed for 3 hrs
  2. temperaturereflux
  3. customThe solids which precipitate
  4. temperatureon cooling
  5. filtrationare filtered
  6. dissolutionpartially dissolved
  7. filtrationfiltered
  8. temperatureThe isopropanol filtrate is cooled
  9. additiontreated with diethyl ether
  10. filtrationThe crystallized product is filtered
  11. customdried
  12. customto give 1.03 g

出典と根拠

ORDレコード
ord-8a708d5803164077b7f4629a7c0c7d9b
出典データセット
uspto-grants-1978_12
特許番号
US04129567

関連ノート

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