Nitric Acid → 4-amino-3-nitrophenylPropanoic acid

HRID 660278

反応式

HRID 660278 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[N+:13]([O-])([OH:15])=[O:14].O>CC(O)=O>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])=[CH:6][C:7]=1[N+:13]([O-:15])=[O:14]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 962WaterHCID 430264-Aminohydratropic acid

生成物 1

HCID 122268174-amino-3-nitrophenylPropanoic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 2-(4-Aminophenyl)propanoic acid (8.45 g, 51.2 mmol) in AcOH (70 mL) was added HNO3 (60%, 5.66 g) at room temperature. The reaction mixture was refluxed for 4 hrs then cooled to room temperature. The mixture was poured into iced water (200 mL), and extracted with CH2Cl2. The organic layer was dried over MgSO4, filtered, and concentrated in vacuo.

後処理

  1. temperatureThe reaction mixture was refluxed for 4 hrs
  2. extractionextracted with CH2Cl2
  3. dry with materialThe organic layer was dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-19d595998b3a4f71862231140536bfd5
出典データセット
uspto-grants-2011_12
特許番号
US08084484B2

関連ノート

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