2-(4-Nitrophenyl)propionic acid → 4-Aminohydratropic acid
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:6][CH:5]=1)([O-])=O>C1COCC1.CCO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:8][CH:9]=1参加物
5
実験手順
To a stirred solution of 2-(4-nitrophenyl)propionic acid (2.05 g) in THF (20 mL) and EtOH (20 mL) was slowly added 10% Pd/C (0.21 g) at room temperature. After hydrogenated for 2 h with H2 balloon, the reaction mixture was filtered through celite pad and washed with EtOH. The filtrate was concentrated in vacuo to afford the product as pale brown solid. (1.75 g, quantitative)
後処理
- customat room temperature
- filtrationthe reaction mixture was filtered through celite pad
- washwashed with EtOH
- concentrationThe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-ae78d0401a8b4ca7a923ce6f9ad8b273
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08084484B2
反応ノート
読み込み中…