2-(4-Nitrophenyl)propionic acid → 4-Aminohydratropic acid

HRID 660330

反応式

HRID 660330 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:6][CH:5]=1)([O-])=O>C1COCC1.CCO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:8][CH:9]=1

参加物

5

反応物 1

HCID 892442-(4-Nitrophenyl)propionic acid

生成物 1

HCID 430264-Aminohydratropic acid

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of 2-(4-nitrophenyl)propionic acid (2.05 g) in THF (20 mL) and EtOH (20 mL) was slowly added 10% Pd/C (0.21 g) at room temperature. After hydrogenated for 2 h with H2 balloon, the reaction mixture was filtered through celite pad and washed with EtOH. The filtrate was concentrated in vacuo to afford the product as pale brown solid. (1.75 g, quantitative)

後処理

  1. customat room temperature
  2. filtrationthe reaction mixture was filtered through celite pad
  3. washwashed with EtOH
  4. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-ae78d0401a8b4ca7a923ce6f9ad8b273
出典データセット
uspto-grants-2011_12
特許番号
US08084484B2

関連ノート

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