反応式
C([O:3][C:4]([C:6]1[S:7][C:8]([CH:11]([O:13][C:14]2[CH:19]=[C:18]([CH3:20])[C:17]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([CH3:30])([CH3:29])[CH3:28])=[CH:23][CH:22]=3)=[C:16]([CH3:31])[CH:15]=2)[CH3:12])=[CH:9][CH:10]=1)=[O:5])C.[OH-].[Li+].Cl>C1COCC1>[C:27]([C:24]1[CH:23]=[CH:22][C:21]([C:17]2[C:18]([CH3:20])=[CH:19][C:14]([O:13][CH:11]([C:8]3[S:7][C:6]([C:4]([OH:5])=[O:3])=[CH:10][CH:9]=3)[CH3:12])=[CH:15][C:16]=2[CH3:31])=[CH:26][CH:25]=1)([CH3:30])([CH3:28])[CH3:29]参加物
5
反応物 3
生成物 1
試薬・触媒・溶媒 1
反応条件
- 温度
- 70 °C
実験手順
To a mixture of (±)-5-[1-(4′-tert-butyl-2,6-dimethyl-biphenyl-4-yloxy)-ethyl]-thiophene-2-carboxylic acid ethyl ester (0.603 g, 1.38 mmol) in THF (14 mL) is added lithium hydroxide (1N aqueous, 14 mL). The mixture is warmed to 70° C. and stirred overnight. The reaction mixture is acidified with 1N HCl (15 mL), extracted into ethyl acetate (3×25 mL), dried over MgSO4, and concentrated, to provide (±)-5-[1-(4′-tert-butyl-2,6-dimethyl-biphenyl-4-yloxy)-ethyl]-thiophene-2-carboxylic acid (0.554 g, 98%) as a white foam. MS (ES): 407.3 [M−H]−.
後処理
- extractionextracted into ethyl acetate (3×25 mL)
- dry with materialdried over MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-3f215e587f1748f19913e56926a47b0e
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08084489B2
関連ノート
読み込み中…