2-(3-Nitrophenyl)oxazolo[4,5-b]pyridine → 3-(Oxazolo[4,5-b]pyridin-2-yl)aniline

HRID 66351

反応式

HRID 66351 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[O:11][C:12]3[C:13]([N:18]=2)=[N:14][CH:15]=[CH:16][CH:17]=3)[CH:7]=[CH:8][CH:9]=1)([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[O:11][C:12]3[C:13]([N:18]=2)=[N:14][CH:15]=[CH:16][CH:17]=3)[CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 1

HCID 124613742-(3-Nitrophenyl)oxazolo[4,5-b]pyridine

生成物 1

HCID 6110863-(Oxazolo[4,5-b]pyridin-2-yl)aniline

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 700mg. of 2-(3-nitrophenyl)oxazolo[4,5-b]pyridine in 50 ml. of ethanol was hydrogenated over 150 mg. of 5% palladium-on-carbon catalyst. The catalyst was removed by filtration and the solvent was concentrated to dryness. The residue was recrystallized from chloroform-petroleum ether to give 2-(3-aminophenyl)oxazolo[4,5-b]pyridine, m.p. 179°-180.5° C.

後処理

  1. additionA mixture of 700mg
  2. customThe catalyst was removed by filtration
  3. concentrationthe solvent was concentrated to dryness
  4. customThe residue was recrystallized from chloroform-petroleum ether

出典と根拠

ORDレコード
ord-08c5e003bb1e44bfb83ec6053d9066fd
出典データセット
uspto-grants-1978_12
特許番号
US04131677

関連ノート

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