4-Bromophenol → tert-butyl (3R)-4-(4-hydroxyphenyl)-3-methylpiperazine-1-carboxylate
反応式
C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1.Oc1ccc(Br)cc1>C1CCOC1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)[O-].[K+].[Pd]>C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ccc(O)cc1参加物
7
反応物 2
生成物 1
試薬・触媒・溶媒 4
反応条件
- 温度
- 100 °C
実験手順
A mixture of (R)-tert-butyl 3-methylpiperazine-1-carboxylate (0.025 g, 0.12 mmol), 4-bromophenol (0.043 g, 0.25 mmol), bis(tri-t- butylphosphine)palladium(0) (6.38 mg, 0.01 mmol) and [Reactants] in THF (2 mL) was flushed with nitrogen and sealed into a microwave tube. The reaction was heated to 100 °C for 20 minutes in the microwave reactor and cooled to RT. No trace of desired product by LCMS. The reaction was not progressed further.
出典と根拠
- ORDレコード
- ord-512d2d9fb0454cb39e6db5113f92b34b
- 出典データセット
- 750 AstraZeneca ELN dataset
- 元リンク
- 出典を表示
反応ノート
読み込み中…