L-Proline → HCID 70543739、化合物
反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([CH2:8]/[CH:9]=[CH:10]/[C:11]([OH:13])=O)=[O:7].[NH:14]1[CH2:21][CH2:20][CH2:19][C@H:15]1[C:16]([OH:18])=[O:17]>O1CCCC1>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([CH2:8]/[CH:9]=[CH:10]/[C:11]([N:14]1[CH2:21][CH2:20][CH2:19][C@H:15]1[C:16]([OH:18])=[O:17])=[O:13])=[O:7]参加物
4
実験手順
To a mixture of 0.02 moles of 4-(2-furoyl)crotonic acid in 100 ml. of tetrahydrofuran is added 0.022 moles of N,N'-carbonyldiimidazole. The mixture is stirred for 3 hours at room temperature and 0.021 moles of L-proline are added. The mixture is refluxed 2 hours and stirred at room temperature for 16 hours to give 1-[4-(2-furoyl)crotonyl]-L-proline.
後処理
- temperatureThe mixture is refluxed 2 hours
- stirringstirred at room temperature for 16 hours
出典と根拠
- ORDレコード
- ord-28d2c344b1404698943077368f2eb37f
- 出典データセット
- uspto-grants-1982_08
- 特許番号
- US04342690
反応ノート
読み込み中…