Phenyl Isothiocyanate → N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea

HRID 66562

反応式

HRID 66562 の反応式
C(N(CC)CC)C.Br.[CH3:9][N:10]1[CH2:14][CH2:13][N:12]([CH3:15])[C:11]1=[NH:16].[C:17]1([N:23]=[C:24]=[S:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(Cl)(Cl)Cl>[CH3:9][N:10]1[CH2:14][CH2:13][N:12]([CH3:15])[C:11]1=[N:16][C:24]([NH:23][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[S:25]

参加物

5

反応物 3

HCID 7673Phenyl IsothiocyanateHCID 8471TriethylamineHCID 134927221,3-Dimethyl-2-imino-imidazolidine hydrobromide

生成物 1

HCID 20530303N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

30.4 g (0.3 mol) of triethylamine are added to a suspension of 58.2 g (0.3 mol) of 1,3-dimethyl-2-imino-imidazolidine hydrobromide in 470 ml of chloroform, at 5°, with stirring. A solution of 40.6 g (0.3 mol) of phenyl isothiocyanate in 235 ml of chloroform is then added dropwise and the reaction mixture is refluxed for 15 hours. After cooling, it is washed with water, dried over sodium sulfate and evaporated in vacuo. Crude N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea is obtained and after recrystallisation from ethanol this melts at 195°-196°.

後処理

  1. temperaturethe reaction mixture is refluxed for 15 hours
  2. temperatureAfter cooling
  3. washit is washed with water
  4. dry with materialdried over sodium sulfate
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-3610284790264e4e93319b0dd2f35d2c
出典データセット
uspto-grants-1982_08
特許番号
US04342764

関連ノート

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