Water → 6-Hydroxyquinoline-5-carbaldehyde

HRID 66598

反応式

HRID 66598 の反応式
[OH-:1].[Na+].[OH2:3].O[C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[CH:10][CH:9]=[CH:8]2.[CH:15](Cl)(Cl)Cl>>[OH:1][C:5]1[CH:14]=[CH:13][C:12]2[N:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:6]=1[CH:15]=[O:3]

参加物

5

反応物 4

HCID 962WaterHCID 6212Chloroform2 回HCID 113746-HydroxyquinolineHCID 14798Sodium Hydroxide

生成物 1

HCID 135600936-Hydroxyquinoline-5-carbaldehyde

反応条件

温度
90 °C

実験手順

Sodium hydroxide (25 g.) was dissolved in 35 ml. of water with cooling, 6-hydroxyquinoline (5 g.) in 15 ml. of chloroform was added and the reaction mixture heated to reflux (about 90° C.) for 12 hours, during which two further 15 ml. portions of chloroform were added--one after 2 hours and the other after 6 hours. The reaction mixture was cooled and crude product recovered by filtration. The crude was dissolved in 125 ml. of hot water treated with activated carbon, filtered hot, cooled and acidified with acetic acid and filtered to yield title product [2.5 g.; m.p 136°-137° C.; m/e 173; pnmr/CDCl3 shows aldehyde proton at 10.5 ppm and aromatic protons at 7.2-9.4 ppm⟧

後処理

  1. temperaturethe reaction mixture heated
  2. waitthe other after 6 hours
  3. temperatureThe reaction mixture was cooled
  4. filtrationcrude product recovered by filtration
  5. dissolutionThe crude was dissolved in 125 ml
  6. additionof hot water treated with activated carbon
  7. filtrationfiltered hot
  8. temperaturecooled
  9. filtrationfiltered

出典と根拠

ORDレコード
ord-12a8023b7b894ac3bb091ca882f9c9db
出典データセット
uspto-grants-1982_08
特許番号
US04342771

関連ノート

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