Dimethyl Sulfoxide → 2-(4-Chlorophenoxy)acetonitrile
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:16][C:17]#[N:18].CS(C)=O>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:16][C:17]#[N:18])=[CH:4][CH:3]=1参加物
6
実験手順
A mixture of 64.25 g of 4-chlorophenol, 98 g of anhydrous potassium carbonate, 40 g of chloroacetonitrile and 100 ml of dimethyl sulfoxide was heated with stirring in a 500 ml round-bottomed three-necked flask at 70°-80° C. for 3.0 hours. The reaction mixture was then poured into ice and water. After the ice melted, the mixture was filtered and the product washed well with water which gave 77.5 g of 4-chlorophenoxyacetonitrile.
後処理
- temperaturewas heated
- filtrationthe mixture was filtered
- washthe product washed well with water which
出典と根拠
- ORDレコード
- ord-9c18c5a5f562428fb1f2d2a6984cc88c
- 出典データセット
- uspto-grants-1982_08
- 特許番号
- US04343809
反応ノート
読み込み中…