Dimethyl Sulfoxide → 2-(4-Chlorophenoxy)acetonitrile

HRID 66728

反応式

HRID 66728 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:16][C:17]#[N:18].CS(C)=O>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:16][C:17]#[N:18])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 46844-ChlorophenolHCID 7856ChloroacetonitrileHCID 11430Potassium Carbonate

生成物 1

HCID 3064442-(4-Chlorophenoxy)acetonitrile収率 92.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 64.25 g of 4-chlorophenol, 98 g of anhydrous potassium carbonate, 40 g of chloroacetonitrile and 100 ml of dimethyl sulfoxide was heated with stirring in a 500 ml round-bottomed three-necked flask at 70°-80° C. for 3.0 hours. The reaction mixture was then poured into ice and water. After the ice melted, the mixture was filtered and the product washed well with water which gave 77.5 g of 4-chlorophenoxyacetonitrile.

後処理

  1. temperaturewas heated
  2. filtrationthe mixture was filtered
  3. washthe product washed well with water which

出典と根拠

ORDレコード
ord-9c18c5a5f562428fb1f2d2a6984cc88c
出典データセット
uspto-grants-1982_08
特許番号
US04343809

関連ノート

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