Methyl iodide → HCID 20529171、化合物

HRID 66821

反応式

HRID 66821 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][C:13]([CH3:18])=[C:12]2[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[CH3:28]I>CN(C)C=O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH3:28])[C:13]([CH3:18])=[C:12]2[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 205292015-Benzyloxy-3-(3-chloro-phenyl)-2-methyl-1H-indole

生成物 1

HCID 20529171HCID 20529171、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

An amount of 3.21 g (9.25 m mole) of 5-benzyloxy-3-(3-chloro-phenyl)-2-methyl-1H-indole was dissolved in 50 ml of absolute dimethylformamide, and the solution was mixed with 406 mg (9.3 m mole) of 55% sodium hydride in paraffin oil. After one hour 1.45 g (10.2 m mole) of methyliodide were added, and the mixture was stirred overnight. After evaporation, the reaction mixture was mixed with water and extracted with chloroform. The extracts, which were dried over sodium sulfate, were evaporated, and the residue obtained was purified by chromatography on silicagel by using toluene as solvent.

後処理

  1. customAfter evaporation
  2. additionthe reaction mixture was mixed with water
  3. extractionextracted with chloroform
  4. dry with materialThe extracts, which were dried over sodium sulfate
  5. customwere evaporated
  6. customthe residue obtained
  7. customwas purified by chromatography on silicagel

出典と根拠

ORDレコード
ord-9be5438826f3452d949f2a84691685a7
出典データセット
uspto-grants-1982_08
特許番号
US04343811

関連ノート

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