Sodium Hydroxide → HCID 3059434、化合物

HRID 66908ノート

反応式

HRID 66908 の反応式
[CH3:1][C:2]([O:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH2:16][CH2:17][CH3:18])[C:11]([CH3:19])=[C:10]2[C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1)([CH3:5])[CH2:3][OH:4].[OH-].[Na+].[Mn]([O-])(=O)(=O)=[O:29].[K+]>O1CCOCC1.O>[CH3:1][C:2]([O:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH2:16][CH2:17][CH3:18])[C:11]([CH3:19])=[C:10]2[C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1)([CH3:5])[C:3]([OH:29])=[O:4]

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 516875Potassium PermanganateHCID 20529122HCID 20529122、化合物

生成物 1

HCID 3059434HCID 3059434、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 312751,4-Dioxane溶媒

実験手順

An amount of 3.38 g (10 m mole) of 2-methyl-2-[2-methyl-1-propyl-3-(4-pyridyl)-1H-indole-5-yloxy]propanol in 50 ml of dioxane was successively mixed with 300 mg of sodium hydroxide in 5 ml of water and then with 3.4 g of potassium permanganate dissolved in 30 ml of water. After stirring for 12 hours, the reaction mixture was filtered, evaporated, and neutralized with dilute sulfuric acid. After extraction with chloroform, the organic phase was dried over sodium sulfate and evaporated. The evaporation residue was recrystallized from ethanol.

後処理

  1. filtrationthe reaction mixture was filtered
  2. customevaporated
  3. extractionAfter extraction with chloroform
  4. dry with materialthe organic phase was dried over sodium sulfate
  5. customevaporated
  6. customThe evaporation residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-47e4be5935044b9eb9e6ff96489fdc5c
出典データセット
uspto-grants-1982_08
特許番号
US04343811

反応ノート

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